Microcap Ledger

Rankings

Biggest microcap movers of September 2026

September's biggest micro-cap gainers and losers, the most +20% days, the heaviest trading, the biggest volume surges, the widest ranges and the sharpest spike-and-fades.

By Microcap Ledger desk · Published

A record of past price moves from exchange data, not a list of stocks to buy or sell.

Sep 1, 2026 to Sep 30, 2026 · 21 sessions · 1,253 stocks ranked · Latest rankings, updated after each close

Ranked from end-of-day prices for 1,253 Nasdaq and NYSE American micro-caps over the 21 sessions of September 2026. DataMeds AI ($MEDS) shows up in six of the eight top-10 lists, including second for gains, first for range, second for volume increase, and ninth for spike and fade. That last list matters because a lot of micro-caps spike and then fall back later: every stock in its top 25 ended September at least half below its high for the month.

Biggest gainers

PDS Biotechnology ($PDSB) led September, up 250.8% from its August 31 close of $0.214 to $0.7507, and closed up 20% or more on four separate days. DataMeds AI ($MEDS, +229.2%) and Stablecoin Development ($SDEV, +174.0%) were next. Six stocks at least doubled.

#StockChangeClose
1 $PDSB PDS Biotechnology Corp Why it moved +250.8% $0.214 → $0.7507
2 $MEDS DataMeds AI, Inc. +229.2% $0.963 → $3.17
3 $SDEV Stablecoin Development Corp +174.0% $0.9452 → $2.59
4 $ETS Elite Express Holding Inc. +114.2% $0.8356 → $1.79
5 $FEAM 5E Advanced Materials, Inc. +110.6% $1.60 → $3.37
6 $INDP Indaptus Therapeutics, Inc. +100.9% $1.15 → $2.30
7 $MGLD Marygold Companies, Inc. +87.5% $1.04 → $1.95
8 $CYPH Cypherpunk Technologies Inc. +82.5% $1.82 → $3.33
9 $COSM Cosmos Health Inc. +77.1% $0.2428 → $0.4299
10 $FTFT Future FinTech Group Inc. +74.4% $1.95 → $3.40
11 $NCPL Netcapital Inc. +73.3% $0.7156 → $1.24
12 $FFR FF EAI Robotics Ecosystem Inc. +61.0% $0.8135 → $1.31
13 $BNKK Bonk, Inc. +61.0% $1.23 → $1.98
14 $MNTK Montauk Renewables, Inc. +58.7% $1.72 → $2.73
15 $QNME Quanome Technologies, Inc. +57.4% $0.338 → $0.532
16 $REFR Research Frontiers Inc +57.3% $0.4671 → $0.7347
17 $TELA TELA Bio, Inc. +55.8% $0.738 → $1.15
18 $AOUT American Outdoor Brands, Inc. +53.3% $10.57 → $16.20
19 $VERI Veritone, Inc. +49.9% $0.7937 → $1.19
20 $LFCR Lifecore Biomedical, Inc. \de\ +47.5% $4.46 → $6.58
21 $GPRO GoPro, Inc. +47.2% $0.8762 → $1.29
22 $VNCE Vince Holding Corp. +47.2% $6.84 → $10.07
23 $PRTH Priority Technology Holdings, Inc. +46.9% $5.31 → $7.80
24 $ATER Aterian, Inc. +46.6% $0.40 → $0.5866
25 $SRZN Surrozen, Inc./DE +46.1% $22.02 → $32.18

Biggest losers

Freight Technologies ($FRGT) fell 79.1%, from $1.34 to $0.28. 22nd Century Group ($XXII, −73.8%) and VisionWave Holdings ($VWAV, −73.2%) followed. Every stock in the top 25 lost more than half its value over the month.

#StockChangeClose
1 $FRGT Freight Technologies, Inc. −79.1% $1.34 → $0.28
2 $XXII 22nd Century Group, Inc. −73.8% $3.20 → $0.8401
3 $VWAV VisionWave Holdings, Inc. −73.2% $16.50 → $4.42
4 $ONEN ONE Nuclear Energy Inc. −72.8% $7.89 → $2.15
5 $LEXX Lexaria Bioscience Corp. −72.1% $11.28 → $3.15
6 $SDST Stardust Power Inc. −71.3% $0.37 → $0.106
7 $HLSQ Tessera Defense & Homeland Security Inc. −70.8% $1.37 → $0.4008
8 $ALMS Alumis Inc. −66.1% $21.81 → $7.39
9 $PPCB Propanc Biopharma, Inc. −63.4% $1.35 → $0.494
10 $NXXT Nextnrg, Inc. −63.4% $2.30 → $0.8419
11 $QCLS Q/c Technologies, Inc. −63.3% $2.32 → $0.8511
12 $GCTK Glucotrack, Inc. −61.4% $4.25 → $1.64
13 $LGVN Longeveron Inc. −61.0% $6.90 → $2.69
14 $KITT Nauticus Robotics, Inc. −60.8% $4.87 → $1.91
15 $SSM Sono Group N.V. −58.2% $2.68 → $1.12
16 $FCUV Focus Universal Inc. −57.9% $9.85 → $4.15
17 $TCRX TScan Therapeutics, Inc. −56.9% $0.7297 → $0.3145
18 $CMPX Compass Therapeutics, Inc. −56.5% $2.39 → $1.04
19 $XLAB Exascale Labs Holdings Inc. −55.7% $4.18 → $1.85
20 $CRMT Americas Carmart Inc −55.6% $2.30 → $1.02
21 $NMRA Neumora Therapeutics, Inc. −55.2% $1.33 → $0.5962
22 $LONA LeonaBio, Inc. −54.9% $7.92 → $3.57
23 $RENT Rent the Runway, Inc. −53.6% $3.56 → $1.65
24 $HCWB HCW Biologics Inc. −52.4% $3.59 → $1.71
25 $KUST Kustom Entertainment, Inc. −52.1% $8.84 → $4.23

Most +20% days

Netcapital ($NCPL) and FF EAI Robotics Ecosystem ($FFR) each closed up 20% or more on five days; Netcapital ranks first on the larger single-day gain. Future FinTech ($FTFT) had four, including a +179.2% close. Eleven stocks had three or more such days.

#Stock+20% daysDetail
1 $NCPL Netcapital Inc. 5 days best +36.4% · period +73.3%
2 $FFR FF EAI Robotics Ecosystem Inc. 5 days best +32.7% · period +61.0%
3 $FTFT Future FinTech Group Inc. 4 days best +179.2% · period +74.4%
4 $PDSB PDS Biotechnology Corp Why it moved 4 days best +69.2% · period +250.8%
5 $BIAF bioAffinity Technologies, Inc. 4 days best +63.6% · period +43.9%
6 $INDP Indaptus Therapeutics, Inc. 4 days best +51.6% · period +100.9%
7 $MEDS DataMeds AI, Inc. 3 days best +274.7% · period +229.2%
8 $APUS Apimeds Pharmaceuticals US, Inc. 3 days best +114.8% · period +28.9%
9 $SDEV Stablecoin Development Corp 3 days best +108.3% · period +174.0%
10 $GIPR Generation Income Properties, Inc. 3 days best +63.4% · period +7.3%
11 $GPRO GoPro, Inc. 3 days best +40.4% · period +47.2%
12 $WHLR Wheeler Real Estate Investment Trust, Inc. 2 days best +190.9% · period −46.9%
13 $VEEA Veea Inc. Why it moved 2 days best +149.3% · period +20.6%
14 $TNON Tenon Medical, Inc. 2 days best +117.2% · period −9.7%
15 $QNME Quanome Technologies, Inc. 2 days best +92.3% · period +57.4%
16 $DBGI Digital Brands Group, Inc. 2 days best +81.1% · period −25.2%
17 $SOAR Volato Group, Inc. 2 days best +77.6% · period +42.8%
18 $TRUG TruGolf Holdings, Inc. 2 days best +76.1% · period −36.9%
19 $AIFF Firefly Neuroscience, Inc. 2 days best +68.9% · period +36.6%
20 $TPST Tempest Therapeutics, Inc. 2 days best +60.2% · period −23.5%
21 $BFRG BullFrog AI Holdings, Inc. 2 days best +58.3% · period +12.3%
22 $ZEO Zeo Energy Corp. 2 days best +57.0% · period +40.6%
23 $PFSA Profusa, Inc. 2 days best +47.8% · period −34.0%
24 $BYSI BeyondSpring Inc. 2 days best +44.1% · period +24.1%
25 $HOST Host Digital Inc. 2 days best +40.5% · period −43.5%

Most dollar volume

Strive ($ASST) traded $5.46 billion of stock in September, about $260 million a session. GoPro ($GPRO, $2.43 billion) and bioAffinity Technologies ($BIAF, $1.80 billion) were next; bioAffinity also had four +20% days.

#StockDollar volumeAverage
1 $ASST Strive, Inc. $5.46B $260.15M a day
2 $GPRO GoPro, Inc. $2.43B $115.64M a day
3 $BIAF bioAffinity Technologies, Inc. $1.80B $85.79M a day
4 $TNON Tenon Medical, Inc. $1.69B $80.24M a day
5 $SLS SELLAS Life Sciences Group, Inc. $1.64B $78.26M a day
6 $FTFT Future FinTech Group Inc. $1.60B $76.16M a day
7 $MEDS DataMeds AI, Inc. $1.50B $71.59M a day
8 $VEEA Veea Inc. Why it moved $1.42B $67.42M a day
9 $CYPH Cypherpunk Technologies Inc. $1.20B $57.18M a day
10 $NUAI New ERA Energy & Digital, Inc. $1.14B $54.37M a day
11 $HYMC Hycroft Mining Holding Corp $976.93M $46.52M a day
12 $ALMS Alumis Inc. $975.38M $46.45M a day
13 $QMCO Quantum Corp /de/ $925.57M $44.07M a day
14 $CMPS COMPASS Pathways plc $806.79M $38.42M a day
15 $SDEV Stablecoin Development Corp $767.37M $36.54M a day
16 $DAIC CID Holdco, Inc. $739.04M $35.19M a day
17 $APUS Apimeds Pharmaceuticals US, Inc. $716.82M $34.13M a day
18 $PDSB PDS Biotechnology Corp Why it moved $709.28M $33.78M a day
19 $FEIM Frequency Electronics Inc $664.75M $31.65M a day
20 $SUNE SUNation Energy, Inc. $653.48M $31.12M a day
21 $WHLR Wheeler Real Estate Investment Trust, Inc. $633.97M $30.19M a day
22 $IRD Opus Genetics, Inc. $591.57M $28.17M a day
23 $SATL Satellogic Inc. $590.78M $28.13M a day
24 $SRZN Surrozen, Inc./DE $578.38M $27.54M a day
25 $TRUG TruGolf Holdings, Inc. $557.87M $26.57M a day

Biggest one-day volume spike

BIO-key International ($BKYI) traded 169.6 million shares on September 29, about 11,300 times its median of the previous 20 sessions, and closed up 85.7%. Veea ($VEEA) on September 15 and Decoy Therapeutics ($DCOY) on September 22 had the next biggest spikes.

#Stockvs 20-day medianDay
1 $BKYI BIO KEY International Inc Why it moved 11,262× Sep 29, 2026 · close +85.7%
2 $VEEA Veea Inc. Why it moved 6,373× Sep 15, 2026 · close +149.3%
3 $DCOY Decoy Therapeutics Inc. 4,073× Sep 22, 2026 · close +21.1%
4 $QNME Quanome Technologies, Inc. 3,319× Sep 18, 2026 · close +92.3%
5 $SLND Southland Holdings, Inc. 3,223× Sep 29, 2026 · close +13.1%
6 $SSM Sono Group N.V. 3,002× Sep 1, 2026 · close +77.4%
7 $BFRG BullFrog AI Holdings, Inc. 2,186× Sep 23, 2026 · close +58.3%
8 $AIFF Firefly Neuroscience, Inc. 1,776× Sep 25, 2026 · close +68.9%
9 $CLRO Clearone Inc 1,715× Sep 28, 2026 · close +47.8%
10 $VTGN Vistagen Therapeutics, Inc. 1,605× Sep 23, 2026 · close +46.5%
11 $APUS Apimeds Pharmaceuticals US, Inc. 1,519× Sep 24, 2026 · close +114.8%
12 $MEDS DataMeds AI, Inc. 1,420× Sep 16, 2026 · close +274.7%
13 $FTFT Future FinTech Group Inc. 1,361× Sep 9, 2026 · close +59.5%
14 $CMCT Creative Media & Community Trust Corp 1,329× Sep 30, 2026 · close +52.6%
15 $BIAF bioAffinity Technologies, Inc. 1,295× Sep 1, 2026 · close +44.5%
16 $SUNE SUNation Energy, Inc. 1,247× Sep 9, 2026 · close +90.3%
17 $QCLS Q/c Technologies, Inc. 1,130× Sep 16, 2026 · close +118.5%
18 $OLB OLB Group, Inc. Why it moved 1,007× Sep 9, 2026 · close +22.6%
19 $ZEO Zeo Energy Corp. 908× Sep 22, 2026 · close +57.0%
20 $REFR Research Frontiers Inc 884× Sep 18, 2026 · close +68.5%
21 $GCTK Glucotrack, Inc. 836× Sep 24, 2026 · close +27.1%
22 $FTHM Fathom Holdings Inc. 813× Sep 25, 2026 · close +12.3%
23 $ARAY Accuray Inc 789× Sep 28, 2026 · close +39.4%
24 $TNON Tenon Medical, Inc. 788× Sep 10, 2026 · close +117.2%
25 $SDST Stardust Power Inc. 785× Sep 17, 2026 · close +57.6%

Biggest volume increase

OpenWorld ($OPNW) averaged $9.48 million of trading a day in September against $37,720 a day over the three months before, a 251-fold increase. DataMeds AI (177×) and Veea (140×) were next. Veea is in five of this month's top-10 lists.

#Stockvs prior 3 monthsAverage daily
1 $OPNW OpenWorld, Inc. 251× $9.48M vs $37.7K a day
2 $MEDS DataMeds AI, Inc. 177× $71.59M vs $405.4K a day
3 $VEEA Veea Inc. Why it moved 140× $67.42M vs $482.4K a day
4 $TCRT Alaunos Therapeutics, Inc. Why it moved 105× $3.14M vs $30.0K a day
5 $BFRG BullFrog AI Holdings, Inc. 103× $10.98M vs $107.1K a day
6 $IPDN Professional Diversity Network, Inc. 101× $14.20M vs $140.2K a day
7 $APUS Apimeds Pharmaceuticals US, Inc. 97.7× $34.13M vs $349.4K a day
8 $FTFT Future FinTech Group Inc. 97.6× $76.16M vs $780.0K a day
9 $MGLD Marygold Companies, Inc. 94.8× $1.79M vs $18.9K a day
10 $REFR Research Frontiers Inc 79.1× $3.18M vs $40.2K a day
11 $OLB OLB Group, Inc. Why it moved 59.7× $6.07M vs $101.6K a day
12 $PDSB PDS Biotechnology Corp Why it moved 59.2× $33.78M vs $571.0K a day
13 $AIFF Firefly Neuroscience, Inc. 56.4× $15.13M vs $268.4K a day
14 $BIAF bioAffinity Technologies, Inc. 51.6× $85.79M vs $1.66M a day
15 $FLYE Fly-E Group, Inc. Why it moved 47.8× $9.12M vs $190.7K a day
16 $MNOV Medicinova Inc 38.2× $2.56M vs $67.0K a day
17 $CMCT Creative Media & Community Trust Corp 37.0× $4.60M vs $124.4K a day
18 $ZEO Zeo Energy Corp. 35.0× $13.85M vs $395.7K a day
19 $TPST Tempest Therapeutics, Inc. 35.0× $7.97M vs $227.8K a day
20 $SDEV Stablecoin Development Corp 30.0× $36.54M vs $1.22M a day
21 $AENT Alliance Entertainment Holding Corp 27.4× $2.79M vs $102.1K a day
22 $GRNQ Greenpro Capital Corp. 25.8× $1.97M vs $76.5K a day
23 $SSM Sono Group N.V. 25.3× $11.66M vs $461.4K a day
24 $BNGO Bionano Genomics, Inc. 25.0× $3.95M vs $158.3K a day
25 $PAAI Paradium.AI, Inc. 23.5× $10.79M vs $459.9K a day

Widest trading range

DataMeds AI ($MEDS) traded between $0.8501 on September 10 and $12.31 on September 16, a range of 1,348%: the high was 14.5 times the low. Future FinTech ($FTFT, 699%) and ONE Nuclear Energy ($ONEN, 534%) had the next widest ranges.

#StockHigh vs lowLow to high
1 $MEDS DataMeds AI, Inc. +1348.1% $0.8501 to $12.31
2 $FTFT Future FinTech Group Inc. +698.6% $1.22 to $9.74
3 $ONEN ONE Nuclear Energy Inc. +534.2% $1.90 to $12.05
4 $APUS Apimeds Pharmaceuticals US, Inc. +505.3% $1.51 to $9.14
5 $VEEA Veea Inc. Why it moved +480.5% $1.53 to $8.88
6 $FRGT Freight Technologies, Inc. +472.1% $0.2412 to $1.38
7 $HLSQ Tessera Defense & Homeland Security Inc. +467.8% $0.38 to $2.16
8 $QCLS Q/c Technologies, Inc. +454.6% $0.4201 to $2.33
9 $FCUV Focus Universal Inc. +454.2% $4.15 to $23.00
10 $GIPR Generation Income Properties, Inc. +440.6% $0.32 to $1.73
11 $PDSB PDS Biotechnology Corp Why it moved +437.5% $0.1972 to $1.06
12 $QNME Quanome Technologies, Inc. +435.2% $0.2616 to $1.40
13 $WHLR Wheeler Real Estate Investment Trust, Inc. +427.9% $1.65 to $8.71
14 $SSM Sono Group N.V. +414.3% $1.05 to $5.40
15 $LEXX Lexaria Bioscience Corp. +413.2% $2.80 to $14.37
16 $SDEV Stablecoin Development Corp +403.3% $0.7809 to $3.93
17 $NCPL Netcapital Inc. +386.3% $0.3825 to $1.86
18 $HCTI Healthcare Triangle, Inc. +384.6% $0.65 to $3.15
19 $XXII 22nd Century Group, Inc. +384.0% $0.7852 to $3.80
20 $ARTL Artelo Biosciences, Inc. +355.9% $3.45 to $15.73
21 $TNON Tenon Medical, Inc. +351.7% $2.40 to $10.84
22 $PAAI Paradium.AI, Inc. +323.1% $0.8201 to $3.47
23 $VWAV VisionWave Holdings, Inc. +315.4% $3.90 to $16.20
24 $BIAF bioAffinity Technologies, Inc. +298.2% $5.11 to $20.35
25 $DCOY Decoy Therapeutics Inc. +297.4% $1.92 to $7.61

Spike and fade

ONE Nuclear Energy ($ONEN) reached $12.05 on September 8, 52.7% above its August close, then finished the month at $2.15, 82.2% below that high. Focus Universal ($FCUV) and Tessera Defense & Homeland Security ($HLSQ) gave back 82.0% and 81.4%. DataMeds AI still ended up 229.2% for the month, but 74.2% below its September 16 high.

#StockOff the highDetail
1 $ONEN ONE Nuclear Energy Inc. −82.2% peak +52.7% (Sep 8, 2026) · period −72.8%
2 $FCUV Focus Universal Inc. −82.0% peak +133.5% (Sep 4, 2026) · period −57.9%
3 $HLSQ Tessera Defense & Homeland Security Inc. −81.4% peak +57.4% (Sep 10, 2026) · period −70.8%
4 $SSM Sono Group N.V. −79.3% peak +101.5% (Sep 2, 2026) · period −58.2%
5 $HCTI Healthcare Triangle, Inc. −77.2% peak +281.8% (Sep 23, 2026) · period −13.0%
6 $GIPR Generation Income Properties, Inc. −76.9% peak +365.2% (Sep 18, 2026) · period +7.3%
7 $VEEA Veea Inc. Why it moved −75.6% peak +393.3% (Sep 17, 2026) · period +20.6%
8 $ARTL Artelo Biosciences, Inc. −74.3% peak +147.3% (Sep 23, 2026) · period −36.5%
9 $MEDS DataMeds AI, Inc. −74.2% peak +1178.3% (Sep 16, 2026) · period +229.2%
10 $DCOY Decoy Therapeutics Inc. −74.1% peak +149.5% (Sep 22, 2026) · period −35.4%
11 $IPW iPower Inc. −72.2% peak +113.3% (Sep 15, 2026) · period −40.8%
12 $TRUG TruGolf Holdings, Inc. −68.4% peak +99.6% (Sep 15, 2026) · period −36.9%
13 $TGL Treasure Global Inc −68.4% peak +75.0% (Sep 16, 2026) · period −44.7%
14 $BIAF bioAffinity Technologies, Inc. −67.8% peak +346.3% (Sep 4, 2026) · period +43.9%
15 $HOST Host Digital Inc. −67.7% peak +75.0% (Sep 17, 2026) · period −43.5%
16 $GRNQ Greenpro Capital Corp. −67.0% peak +63.3% (Sep 8, 2026) · period −46.0%
17 $SGLY Singularity Future Technology Ltd. −65.5% peak +63.2% (Sep 10, 2026) · period −43.7%
18 $FTFT Future FinTech Group Inc. −65.1% peak +399.6% (Sep 16, 2026) · period +74.4%
19 $PAAI Paradium.AI, Inc. −64.0% peak +257.7% (Sep 17, 2026) · period +28.9%
20 $DAIC CID Holdco, Inc. −62.5% peak +105.4% (Sep 17, 2026) · period −23.0%
21 $TNON Tenon Medical, Inc. −62.3% peak +139.3% (Sep 11, 2026) · period −9.7%
22 $QNME Quanome Technologies, Inc. −62.0% peak +314.2% (Sep 22, 2026) · period +57.4%
23 $MNOV Medicinova Inc −57.1% peak +171.8% (Sep 17, 2026) · period +16.7%
24 $KPLT Katapult Holdings, Inc. −54.4% peak +77.3% (Sep 8, 2026) · period −19.2%
25 $ZEO Zeo Energy Corp. −54.2% peak +206.8% (Sep 22, 2026) · period +40.6%

How these are built. Regular-session daily bars for 1,258 Nasdaq and NYSE American micro-caps with a ticker page here, split-adjusted, through the September 30, 2026 close. No real-time prices: every figure comes from completed sessions.

  • Gains and losses run from the last close before Sep 1, 2026 to the last close of the period. A +20% day is a close at least 20% above the previous close.
  • A stock is ranked if it traded on at least 15 of the period’s 21 sessions (1 didn’t).
  • Volume spike: the day’s share volume against the median of the 20 sessions before it. The day must trade at least $1.00M and the median at least $25.0K a day.
  • Volume increase: average daily dollar volume in the period against Jun 1, 2026 to the day before the period. Needs at least $1.00M a day in the period and 40 sessions before it.
  • Spike and fade: the period’s high must be at least 50% above the prior close. Ranked by the fall from that high to the last close.
  • Ranges use each session’s high and low.

Left out (4). A one-day close move of +300% or more, or -75% or less, can be a share split the price history doesn’t reflect, so these stocks are left out of every ranking for the period: $AEMD (+374% on Sep 17, 2026), $BENF (+439% on Sep 23, 2026), $JAGX (+1191% on Sep 22, 2026), $XHLD (-92% on Sep 28, 2026).

Data: Alpaca Markets (SIP), daily bars, split-adjusted. A record of past price moves from exchange data, not a list of stocks to buy or sell.

Facts as of . Small caps move fast; check the latest filings.

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